Blar i Bergen Open Research Archive på forfatter "Jersin, Regine Åsen"
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Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism
Jersin, Regine Åsen; Tallapragada, Divya Sri; Skartveit, Linn; Bjune, Mona Synnøve; Muniandy, Maheswary; Lee-Ødegård, Sindre; Heinonen, Sini; Alvarez, Marcus; Birkeland, Kåre Inge; Drevon, Christian André; Pajukanta, Päivi; McCann, Adrian; Pietiläinen, Kirsi H.; Claussnitzer, Melina; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2023)Context The neutral amino acid transporter SLC7A10/ASC-1 is an adipocyte-expressed gene with reduced expression in insulin resistance and obesity. Inhibition of SLC7A10 in adipocytes was shown to increase lipid accumulation ... -
Metabolic and Epigenetic Regulation by Estrogen in Adipocytes
Bjune, Jan-Inge; Strømland, Pouda Panahandeh; Jersin, Regine Åsen; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2022-02-22)Sex hormones contribute to differences between males and females in body fat distribution and associated disease risk. Higher concentrations of estrogens are associated with a more gynoid body shape and with more fat storage ... -
The neutral amino acid transporter SLC7A10 in adipose tissue, obesity and insulin resistance
Jersin, Regine Åsen; Jonassen, Laura Roxana; Dankel, Simon N (Journal article; Peer reviewed, 2022)Obesity, insulin resistance and type 2 diabetes represent major global health challenges, and a better mechanistic understanding of the altered metabolism in these conditions may give improved treatment strategies. SLC7A10, ... -
Role of Adipocyte SLC7A10 and Amino Acid Metabolism in Obesity and Insulin Resistance
Jersin, Regine Åsen (Doctoral thesis, 2020-12-18)Obesity is a rising global concern, associated with increased risk of developing metabolic syndrome, insulin resistance and type 2 diabetes. Chronic availability of excess nutrients may promote adipocyte dysfunction, ... -
Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance
Jersin, Regine Åsen; Tallapragada, Divya Sri Priyanka; Madsen, André; Skartveit, Linn; Fjære, Even; McCann, Adrian; Dyer, Laurence; Willems, Aron; Bjune, Jan-Inge; Bjune, Mona Synnøve; Våge, Villy; Nielsen, Hans Jørgen; Thorsen, Håvard Luong; Nedrebø, Bjørn Gunnar; Busch, Christian; Steen, Vidar M.; Blüher, Matthias; Jacobson, Peter; Svensson, Per-Arne; Fernø, Johan; Rydén, Mikael; Arner, Peter; Nygård, Ottar; Claussnitzer, Melina; Ellingsen, Ståle; Madsen, Lise; Sagen, Jørn V.; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2021)Elucidation of mechanisms that govern lipid storage, oxidative stress, and insulin resistance may lead to improved therapeutic options for type 2 diabetes and other obesity-related diseases. Here, we find that adipose ...